Prior to the vein injection, you should avoid taking certain medications. Talk to the doctor about all medications (including over the counter drugs, herbs, and dietary supplements) you are taking. If you need to take an antibiotic before sclerotherapy, contact your physician. No lotion should be applied to the legs before the procedure. Some physicians recommend avoiding aspirin, ibuprofen (including Advil, Motrin, and Nuprin) or other anti-inflammatory medications for 48-72 hours before sclerotherapy, however, Tylenol should not affect this procedure.